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COMPREHENSIVE NEUROAIDS CENTER (cnac)
NeuroAIDS Related Links
RFA-MH-14-170 - Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics (R01) This Funding Opportunity Announcement (FOA) invites research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART). This FOA will support innovative research in five areas: (1) basic research to identify and characterize persistent HIV-1 in CNS derived cells such as macrophages, microglia, and/or astrocytes in the setting of suppressive anti-retroviral therapy, with or without substance use; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of persistent HIV-1 in CNS in relationship to the timing of antiretroviral therapy; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART including effects of chronic substance use; (4) assessment of current and emerging eradication approaches on whether and/or how well they have successfully reactivated persistent HIV from CNS-derived cells such as macrophages, microglia and astrocytes; and (5) assessment of CNS toxicity and adverse impact of current and emerging eradication strategies. Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required.
This Funding Opportunity Announcement (FOA) invites research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART). This FOA will support innovative research in five areas: (1) basic research to identify and characterize persistent HIV-1 in CNS derived cells such as macrophages, microglia and/or astrocytes in the setting of suppressive anti-retroviral therapy, with or without substance use; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of persistent HIV-1 in CNS in relationship to the timing of antiretroviral therapy; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART, including effects of chronic substance use; (4) assessment of current and emerging eradication approaches on whether and/or how well they have successfully reactivated persistent HIV from CNS-derived cells such as macrophages, microglia and astrocytes; and (5) assessment of CNS toxicity and adverse impact of current and emerging eradication strategies. Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required.
The Johns Hopkins NIMH Center for Novel Therapeutics of HIV-associated Cognitive Disorders The Johns Hopkins NIMH Center is comprised of an interdisciplinary research team who has pooled their talents to study the nature of HIV-associated neurocognitive disorders (HAND). Their aim is to translate discoveries of the pathophysiological mechanisms into novel therapeutics for HAND.
HIV Neurobehavioral Research Center, University of California, San Diego The mission of the HIV Neurobehavioral Research Center (HNRC) is to increase understanding of how HIV and other diseases affect the human nervous system. The HNRC conducts local, national, and international research devoted to advancing our knowledge of the prevention, diagnosis and treatment of HIV-related diseases as they affect the brain and nervous system, and result in impairment of everyday functioning.
Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center, UNMC The now chronic nature of HIV has been a major advancement in AIDS care. While HIV infected individuals are living longer, damaging effects of HIV persist in the brain and may interact with other neurodegenerative disorders. The CHAIN Center at the University of Nebraska Medical Center will research new ways to diagnose, predict, treat and prevent brain damage induced by HIV via a systems biology approach.
CFAR's mission is to support, encourage and facilitate research in all areas of HIV/AIDS by (a) facilitating communication and interdisciplinary collaborations through workshops, working groups, strategic planning efforts, and a seminar series covering all topics in the field; (b) support innovative pilot reaseach in HIV/AIDS through developmental pilot grant programs including nonhuman primate-based research; (c) mentoring and support of junior investigators; (d) services and training in support of HIV research through Shared Cores: Clinical, Viral/Molecular, Immunology, Biostatistics & Data Management; Behavioral and Social Sciences; International; Nonhuman Primate.
Mount Sinai Institute for NeuroAIDS Disparities MSINAD is a collaborative program of the Manhattan HIV Brain Bank and the Center for Multicultural and Community Affairs at the Mount Sinai School of Medicine. The mission of MSINAD is: 1) to stimulate research into NeuroAIDS disorders in minority populations, 2) to provide multidisciplinary education to young scientists interested in pursuing NeuroAIDS research, 3) to encourage entry of scientists from under-represented groups into the field.
International Society for NeuroVirology The International Society for NeuroVirology is an international forum for researchers and clinician scientists involved in the study of neurovirology. The purpose of the Society is to advance collaboration among scientists in all aspects of neurovirology and related disciplines in order to further knowledge in the area, and promote the clinical application of this knowledge to prevent and treat neuroinflammation and pathophysiology of viral encephalitides.
The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system.
The health and research webmagazine.
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Contact Information:Comprehensive NeuroAIDS Center (CNAC) Kamel Khalili, PhD CNAC Director Department of Neuroscience Temple University School of Medicine 3500 N. Broad St., 7th Fl. Philadelphia, PA 19140 T: 215-707-4500 Email: kamel.khalili@temple.edu
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