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Comprehensive NeuroAIDS Center



Clinical and Behavioral Core

We support translational studies and cross-disciplinary investigation in epidemiology, behavioral health, clinical trials, and public health. The Core will expand its longitudinal database from the existing clinical cohorts to include neuropsychiatric and neurocognitive assessment of a large well-characterized urban minority patient population. The core assists in the development, design, and performance of studies that transition basic research to the bedside and at the same time foster the transition of clinical observations and hypotheses to the laboratory. This Core further interacts with the International HIV Medicine and Research Core to provide training in advanced HIV care and neurocognitive assessment that can be used at the international site to both improve the quality of patient care and also to perform meaningful neurocognitive assessment that benefits patients as well as the research community.





Ellen Tedaldi, MD, Leader

Tracy Fischer-Smith, PhD, Co-Leader

Nancy Minniti, PsyD, Co-Leader


The CNAC clinical team


For additional information concerning translational research and clinical investigations, please contact Ellen Tedaldi, MD or Tracy Fischer-Smith, PhD.


Image (below): Click to Enlarge



News & Updates


Clinical and Behavioral Core develops Human Specimen Repository


To further facilitate the mission of this core in bridging the gap between clinical and basic research activities in neuroAIDS, the Clinical and Behavioral Core has recently established the CNAC Clinical Core Human Specimen Repository, through which we are collecting and storing human peripheral blood mononuclear cells (PBMC) and plasma from HIV infected persons recruited through the Temple Comprehensive HIV program. Through this program, investigators have access to blood specimens and clinical data from a highly diverse and well-characterized cohort of HIV infected individuals. Clinical data are collected on all participants, including CD4+ T-cell counts, viral load, illicit drug use, and anti-retroviral therapy regimen. Neuropsychological evaluation data are available for some participants. Specimens are available to investigators to support translational research studies that advance our current understanding of the neuropathogenesis of HIV infection and explore strategies for therapeutic intervention. As an additional mechanism for assisting investigators interested in human subjects research, the Clinical and Behavioral Core also provides mentorship in human subjects protocols and institutional review board (IRB) submission and assesses the feasibility for translational projects. Through these services, the Clinical and Behavioral Core is strategically positioned to engage a broad range of investigators in projects that integrate basic science, neurocognitive, and clinical research questions into complementary protocols with the same study cohort.


To request specimens, please complete this form and return to tlfs@temple.edu.