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about | Maps & Directions | contact | admissions | faculty | alumni & development | library | Tech Support Center | dean's office | Policies & Procedures |
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COMPREHENSIVE NEUROAIDS CENTER (cnac)
Basic Science Core II: Animal Models, Behavioral Testing, Pathology and Histology
This core assists researchers studying AIDS and brain disorders to utilize animal models for evaluating therapeutics and behavioral tests for improving treatments diagnosis and prevention. Moreover, this core provides services to researchers in analyzing human samples and animal tissues for improving diagnosis of disease and understanding the mechanism involved in the pathogenesis of neuroAIDS.
We assist investigators in the development, analysis and characterization of animal models with impaired nervous system function related to HIV-1 and AIDS, including phenotypic characterization of animals at the anatomical level and full-scale behavioral characterization of animals including memory, learning, and other cognitive functions, sensory and motor function, development and aging, neurological and neuromuscular assessment.
For additional information on animal models, please contact Jennifer Gordon, PhD.
For additional information on animal behavioral testing, please contact Mary Barbe, PhD.
To schedule a neuropathology consultation, please email cnac@temple.edu. Consultations are available on Fridays between 9 and 11 a.m. and again between 2 and 4 p.m.
For histopathology and microscopy services, please contact Jennifer Gordon, PhD.
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Contact Information:
Jennifer Gordon, PhD
Yuri Persidsky, MD, PhD Basic Science Core II Co-Leader Neuropathology consultation Department of Pathology and Laboratory Medicine Temple University School of Medicine 3500 N. Broad Street Room 1060, MERB Philadelphia, PA 19140 T: 215-707-4353 yuri.persidsky@tuhs.temple.edu
Mary F. Barbe, PhD Basic Science Core II Co-Leader Animal behavioral testing Department of Anatomy and Cell Biology Temple University School of Medicine 3500 N. Broad Street, 4th Fl. MERB T: 215-707-6422 mary.barbe@temple.edu
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We offer histological and immunohistochemical services for the evaluation of human autopsy and biopsy clinical samples, tissues harvested from experimental animal models, and cell cultures. More specifically, this core pereforms neuropathological evaluation and diagnosis of clinical cases (autopsy and biopsy samples) from patients with neurological disorders including AIDS, PML, neurodegenerative diseases, and CNS neoplasia. Further, this core provides services for immunohistochemical staining, photodocumentation and analysis for expression of cellular and viral proteins as needed. Through its microscopy facilities, this core assists in Laser Capture Microdissection (LCM) accessioning of tissue samples and nucleic acid extraction for downstream molecular biological applications and Two-photon (2P) excitation microscopy of cells and tissues for high resolution and microscopic analysis.