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Bone marrow transplants give patients a chance to beat diseases once believed to have no cure. Some kinds of leukemia and lymphoma were considered untreatable a generation ago. The Fox Chase-Temple Bone Marrow Transplant Program is in its 19th year and has now performed over 900 transplants.

department of medicine

fox chase temple bone marrow transplant program

BMT Program History and Honors

 

On July 1, 1987 Kenneth F. Mangan, MD founded and established the Temple University Bone Marrow Transplant Program at 2400 North Broad Street. The program received an official Commonwealth of Pennsylvania Certificate of Need early in 1988.

  • First autologous BMT was 2/28/88
  • First allogeneic BMT was 11/16/89
  • First autologous PBSCT was 5/16/90
  • First allogeneic PBSCT was 3/14/96
  • First matched unrelated donor BMT was 12/6/96
  • First submyeloablative, mini-allogeneic PBSCT was 5/18/99
  • BMT program moved to the Jeanes campus in Northeast Philadelphia on 4/01/00
  • Over 1,000 transplants performed by 2008

 

Transplant Activity

  • Over 650 autologous blood or marrow stem cell transplants
  • Over 350 allogeneic blood or marrow stem cell transplants
  • Recent transplant activity is over 80 transplants per year
  • Matched related and matched unrelated allogeneic transplants using full myeloablative or submyeloablative regimens
  • Over 2000 apheresis procedures for stem cell collection
  • Capable of purging with photoactive dyes and performing positive CD-34 stem cell selection
  • Over 50 donor lymphocyte infusions for treatment of relapse
  • Over 125 total body irradiation procedures

Special Strengths and Extensive Experience

  • Transplants for patients with acute and chronic leukemia and preleukemia (myelodysplastic syndrome)
  • Extensive experience for transplants of all kinds in patients with various lymphomas, Hodgkin's disease and multiple myeloma
  • Special programs for treatment of patients with severe aplastic anemia and related marrow failure states
  • An autologous stem cell program for treatment of amyloidosis
  • Complete, extensive consultation reports to patients and referring physicians for initial and all subsequent visits
  • Extensive experience with mini-allogeneic transplants and donor lymphocyte infusions

Credentials/Certifications

  • Commonwealth of Pennsylvania Certificate of Need (1998)
  • Level I Accredited by the Foundation for Accreditation of Cellular Therapy. Reaccredited in 2008.
  • Eastern Cooperative Oncology Group Transplant Center
  • Bone Marrow Transplant Clinical Trials Network Center
  • An approved and certified transplant and stem cell collection center for the National Marrow Donor Program
  • Member in good standing of the International Bone Marrow Transplant Registry

Committees and IRB

  • Every protocol is approved by Temple University and/or Fox Chase Cancer Center Research Review
  • Approved protocols may also be independently reviewed by the Physicians Data Query for the National Cancer Institute
  • We participate in cooperative group protocols, pharmaceutical protocols, and investigator-initiated protocols