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The laboratory research focuses on understanding
the remarkable properties of the mammalian oocyte, which exists
as a highly differentiated cell type endowed with the unique capacity
for creating an embryonic genome from the two terminally differentiated
gamete genomes, activating that embryonic genome, and regulating
its function during much of the preimplantation period. The research
seeks to understand these fundamental, life-generating processes
at the molecular level, by employing a combination of microsurgery,
quantitative gene expression analyses, microarray analyses, and
structural studies.
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