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VinhNguyen, M. Waleed Gaber,Marc R. Sontag and MohammadF. Kiani School of Biomedical Engineering and Departmentof Radiation Oncology, University of Tennessee Health Science Center (Radiat. Res., 154(5):531-536, 2000) Damage to the microvascular networks constitutesone of the most important components of ionizing radiation damage to normaltissue. Previously, we have reported the early (3, 7, and 30 days post-irradiation ) effects of ionizing radiation on the structureand function of normal tissue microvascular networks.Here we report on the late effects of ionizing radiation on the structural andfunctional changes in microvascular networks inlocally irradiated (single 10 Gy dose) hamster cremaster muscles observed 60, 120, and 180 dayspost-irradiation; age matched animals were used as control. As in theprevious study, intravital microscopy was used tomeasure structural and functional parameters in complete microvascularnetworks in vivo. A factorial design was used to examine the effects ofradiation status, time post-irradiation, and network vessel type on thestructure and function of microvascularnetworks. Our results indicate that the progression of radiation induced microvascular damage continues during the late time pointsbut there is partial recovery from radiation damage within 6 monthspost-irradiation. Red blood cell flux, red blood cell velocity and capillaryblood flow in irradiated networks at 180 days post-irradiation weresignificantly larger than control. As in the early time points, all vesseltypes were not damaged equally by radiation at every time point. Forward comments or questions to: mkiani@utmem.edu
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