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Education
- NIH Postdoctoral Training Fellow, Biomechanics (1992-1994), Hospital for Special Surgery, New York, NY
- Ph.D. Chemistry, Biophysical Chemistry (1991), Rutgers University, Newark, NJ.
- M.S. Chemistry, Medicinal Chemistry (1988), Rutgers University, Newark, NJ
- B.Sc Chemistry (1985), McGill University, Montreal, Que, Canada
Research Interests
- Vibrational Spectroscopy
- Tissue Engineering
- Tissue Imaging
- Biomechanics
Selected Publications
Bi X, Yang X, Bostrom MPG, Camacho NP. Fourier Transform Infrared Imaging Spectroscopy Investigations in the Pathogenesis and Repair of Cartilage. Biochim Biophys Acta. 2006 Jul;1758(7):934-41
Harmey D, Johnson KA, Zelken J, Camacho NP, Hoylaerts MF, Noda M, Terkeltaub R, Millan JL. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in akp2(-/-) mice. J Bone Miner Res. 2006 Sep;21(9):1377-87.
Spencer RG, Calton EF, Pleshko Camacho N. Statistical Comparison of Fourier Transform Infrared Spectra. J Biomed Optics, 2006 Nov-Dec;11(6):064023.
Bi X, Yang X, Bostrom MPG, Bartusik D, Ramaswamy S, Fishbein KW, Spencer RG, Camacho NP. Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. Anal Bioanal Chem. 2007 Mar;387(5):1601-12
Canuto HC, Fishbein KW, Bajaj P, Pleshko Camacho N, Spencer RG. Optimal Methods for the Preservation of Cartilage Samples in MRI and Correlative Biochemical Studies. J Mag Res, 2007 May;57(5):866-73.
Boskey A, Pleshko Camacho N. Infrared imaging of native and tissue-engineered bone and cartilage. Biomaterials, 2007 May;28(15):2465-78.
Delos D, Yang X, Ricciardi BF, Myers ER, Bostrom MPG, Pleshko Camacho N. The Effects of RANKL Inhibition on Fracture Healing and Bone Strength in a Mouse Model of Osteogenesis Imperfecta. J Orthop Res, Bone. 2007 Dec;41(6):928-36.
Zhang H, Doty S, Hughes C, Dempster DW, Pleshko Camacho N, Increased Resorptive Activity and Accompanying Morphological Alterations in Osteoclasts Derived from a Mouse Model of Osteogenesis Imperfecta (oim/oim), J Cell Biochem, 2007 Nov 1;102(4):1011-20.
Miller E, Delos D, Baldini T, Wright TM, Pleshko Camacho N. Abnormal Mineral-Matrix
Interactions are a Significant Contributor to Fragility in oim/oim bone. Calc Tiss Int, 2007 Sep;81(3):206-14.
Yang X, Ricciardi BF, Hernandez-Soria A, Shi Y, Pleshko Camacho N, Bostrom MP Callus mineralization and maturation are delayed during fracture healing in IL-6 knockout mice. Bone. 2007 Dec;41(6):928-36.
Cheng C, Conte E, Pleshko-Camacho N, Hidaka C. Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix Biol. 2007 Sep;26(7):541-53
Zhang H, Ricciardi BF, Yang X, Shi Y, Camacho NP, Bostrom MPG. Polymethylmethacrylate particles stimulate bone resorption of mature osteoclasts in vitro. Acta Orthop 2008 79:281-288
Millán JL, Narisawa S, Lemire I, Loisel TP, Boileau G, Leonard P, Gramatikova S, Terkeltaub R, Camacho NP, McKee MD, Crine P, Whyte MP. Enzyme Replacement Therapy for Murine Hypophosphatasia. J Bone Miner Res. 2008 Jun;23(6):777-87.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinsky N, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, and de Cabo R. Resveratrol delays age-related deterioration and mimics aspects of dietary restriction in mice on a standard diet .Cell Metab. 2008 Aug;8(2):157-68.
Bargman R, Huang A, Boskey AL, Raggio CL, Pleshko N. RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. Connective Tiss Res, in press.
Kim M, Foo LF, Uggen C, Lyman S, Ryaby JT, Moynihan D, Grande DA, Potter HG, Pleshko N. Evaluation of early osteochondral defect repair in a rabbit model utilizing Fourier transform infrared imaging spectroscopy (FT-IRIS), magnetic resonance imaging (MRI) and quantitative T2 mapping. Tissue Eng Part C Methods. 2009 Jul 8. [Epub ahead of print]
Present Teaching (Fall 2009)
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