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COMMON PEROXIDE-FORMING COMPOUNDS

Peroxide-forming chemicals can be divided into 4 groups. The list is not exhaustive. Refer to the Material Safety Data Sheets (MSDS) before use to determine if there is a possibility of peroxide formation and additional safety information. 

GROUP A. Severe Peroxide Hazard on Storage with Exposure to Air

These chemicals may form explosive levels of peroxide with exposure to air and without concentration by evaporation or distillation. It is important to limit quantities of these chemicals in the laboratory, and be vigilant in regularly inspecting your inventory.

Butadiene (liquid monomer)

Chloroprene (liquid monomer)

Diisopropyl ether (isopropyl ether)

Divinylacetylene (DVA)

Potassium amide

Potassium metal

Sodium amide (sodamide)

Tetrafluoroethylene ( liquid monomer)

Vinylidene chloride (1,1-dichloroethylene)

  • Test for peroxides before each use
  • Dispose of 3 months after opening
  • If unopened, dispose of 1 year after date received or stamped expiration date whichever comes first

GROUP B. Peroxide Hazard on Concentration

These chemicals form explosive levels of peroxide when distilled, evaporated or otherwise concentrated.  Do not distill or evaporate without first testing for peroxides.

Acetal  (acetaldehyde diethyl acetal)

Acetaldehyde

Benzyl alcohol

2-Butanol

Cumene (isopropylbenzene)

Cyclohexanol

Cyclohexene

2-Cyclohexen-1-ol

Decahydronaphthalene  (decalin)

Diacetylene

Dicyclopentadiene

Diethyl ether (ether)

Diethylene glycol dimethyl ether

Diglyme

Dioxane

Glyme

Furan

4-Heptanol

2-Hexanol

Methyl acetylene

3-Methyl-1-butanol

Methyl cyclopentane

Methyl isobutyl ketone

2-Methyl-2-pentanol

2-Pentanol

4-Penten-1-ol

1-Phenylethanol

2-Phenylethanol

2-Propanol

Tetrahydrofuran (THF)

Tetrahydronaphthalene

Vinyl ethers

Other secondary alcohols

  • Test for peroxides before each use
  • Dispose of 3 months after opening (unless tested and free of peroxides)
  • Dispose of within 6 months of opening
  • If unopened, dispose of 1 year after date received or stamped expiration date whichever comes first

GROUP C. Hazard of Rapid polymerization initiated by internally formed peroxide

These chemicals are highly reactive and may auto-polymerise and explode as a result of peroxide accumulation.  The peroxides formed in these reactions are extremely shock and heat sensitive.

Acrylic acid

Acrylonitrile

Butadiene (gas)

Chloroprene (gas)

Chlorotrifluorethylene

Methyl methacrylate

Styrene

Tetrafluoroethylene (gas)

Vinyl acetate

Vinylacetylene ( gas)

Vinyladiene chloride

Vinyl chloride (gas)

Vinylpyridines

  • Test for peroxides before each use
  • Dispose of 3 months after opening (unless tested and free of peroxides)
  • After opening, materials without inhibitors should not be stored for longer than 24 hours
  • Dispose of within 6 months of opening
  • If unopened, dispose of 1 year after date received or stamped expiration date whichever comes first

GROUP D. Potential Peroxide Formers

Over 200 organic and inorganic compounds are capable of forming peroxides under the right conditions.  The chemical owner should refer to MSDS, contact the chemical manufacturer, or contact EHRS to determine if chemicals are potential peroxide formers. 

Acrolein

Allyl ether

Ally ethyl ether

Allyl phenyl ether

p-(n-amyloxy) benzoyl chloride

n-Amyl ether

Benzyl n-butyl ether

Benzyl ether

Benzyl ethyl ether

Benzyl methyl ether

Benzyl 1-naphthyl ether

1,2-Bis(2-chloroethoxy)-ethane

Bis(2 ethoxyethyl)ether

Bis(2(methoxyethoxy)-ethyl) ether

Bis(2-chloroethyl) ether

Bis(2-ethoxyethyl) adipate

Bis(2-ethoxyethyl) phthalate

Bis(2-methoxyethyl) carbonate

Bis(2-methoxyethoxy)ethyl ether)

Bis(2-methoxyethyl) phthalate

Bis(2-methoxymethyl) adipate

Bis(2-n-butoxyethyl) phthalate

Bis(2-phenoxyethyl) ether

Bis(4-chlorobutyl) ether

Bis(chloromethyl) ether

2-Bromomethyl ethyl ether

beta-Bromophenetole

o-Bromophenetole

p-Bromophenetole

3-Bromopropyl phenyl ether

p-Chlorophenetole

Cyclooctene

Cyclopropyl methyl ether

Diallyl ether

p-Di-n-butoxybenzene

1,2,-Dibenzyloxybenzene

p-Dibenzyloxybenzene

1,2-Dichloroethyl ethyl ether

2,4-dichlorophenetole

Diethoxymethane

2,2-Diethoxypropane

Diethyl ethoxymethylene-malonate

Diethyl fumarate

Diethyl acetal

Diethylketene

1,2,-Diethoxyethane

Dimethoxymethane

1,1-Dimethoxyethane

Dimethylketene

3,3,-Dimethoxypropene

2,4-Dinitrophenetole

1,3-Dioxepane

Di(1-propynyl) ether

Di(2-propynyl)ether

Di-n-propoxymethane

1,2-Epoxy-3-isopropoxypropane

1,2-Epoxy-3-phenoxypropane

p-ethoxyacethophenone

1-(2-Ethoxyethoxy)ethyl acetate

4,5-Hexadien-2-yn-1-ol

n-Hexyl ether

Isoamyl benzyl ether

Isoamyl ether

Isobutyl vinyl ether

Isophorone

beta-isopropoxypropionitrile

Limonene

1,5-p-menthadiene

Methyl p-(n-amloxy)benzoate

4-Methyl-2-pentanone

2-methyltetrahydrofuran

2-Methytetra-hydrofuran

3-Methoxy-1-butyl acetate

2-methoxyethanol

beta-methoxypropionitrile

m-Nitrophenetole

1-Octene

Pentene

Phenoxyacetyl chloride

1-Phenoxypropionyl-hloride

Phenyl o-propyl ether

n-Propyl ether

  • Test for peroxides before each use
  • Recommended disposal of 12 months after opening.
  • If unopened, recommended disposal after 18 months. Consult MSDS for storage time limits
  • Dispose of after stamped expiration date or as listed on MSDS