The
goal of biological chemistry is to understand
the structure, organization and functions of living
matter in molecular terms.
The
current research program in biological chemistry
at
Temple centers around the common themes of bioinformatics,
bioorganic chemistry, biophysical chemistry,enzymology,and
molecular biology.
Faculty, including Professors Allen
Nicholson, Chris
Schafmeister, and Robert
Stanley have established research projects
that reflect the multidisciplinary nature of the
field, including:
- the
synthesis of biologically active molecules
- spectroscopic
study of the DNA repair reaction mechanism catalyzed
by photolyase
- protein-DNA
interaction
- sequence/structure
relationship of proteins
- enzymatic
mechanism and kinetics of Ribonucleases in RNA
processing
- microarray
studies of the activated signaling pathways
in cancer.
You
are invited to contact any one of us for further
information.
Recent
publications include:
Pertzev,
AV., Nicholson, A.W. "Characterization of
RNA sequence determinants and antideterminants
of processing reactivity for a minimal substrate
of Escherichia coli ribonuuclease III." Nucleic
Acids Res. 34: 3708-3721 (2006).
Siddiqui
MSU.; Stanley RJ. “A cryogenic optical waveguide
spectrometer for the measurement of low-temperature
absorption spectra of dilute biological samples”.
Analytical Biochemistry 337 (1): 121-129
(2005).
Sun,
W., Pertzev, A., and Nicholson, A.W. "Catalytic
mechanism of Escherichia coli ribonuclease III.
Kinetic and inhibitor evidence for the involvement
of two magnesium ions in RNA phosphodiester hydrolysis."
Nucleic Acids Res. 33: 807-815 (2005).
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