Susan Jansen-Varnum
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Professor B.S. (1981) University of Missouri – St. Louis
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OFFICE
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Analytical / Environmental / Inorganic / MaterialsResearch InterestsEvaluating Biomarkers of Inflammation of Cardiovascular RiskThe purpose of this research is to understand how gender differences are manifested in cardiac vascular risk. More specifically, are the current clinical risk assessment tools sufficient for therapeutic recommendations? Our hypothesis is that the state of inflammation in cardiac tissues from a variety of metabolic factors and disease provides a more reliable risk assessment tool. Therefore, analytical tools to quantitatively assess the levels of inflammation will be developed; and these methods will be applied to understanding the development of cardiovascular disease and related gender differences using a rat model. Inflammation in Tumor ProgressionWe are interested in the molecular mechanisms that regulate tumor progression in colon cancer. Currently we are developing bioanalytical methods to quantify major eicosanoids that regulate inflammation and tumor growth. Profiling the Course of Hypertensive DiseaseDetermination of creatinine and 8-iso PGF2 from the same urine sample is efficient.. Levels of urinary isoprostane and creatinine are markers of disease progression as is age. In this study, levels of inflammatory biolipids are quantified and correlated with levels of natural sex hormone to profile progression of disease from hypertensive conditions. Understanding Inflammation in Brain Injury and Disease We are interested in understand how resolution of inflammation encourages recovered from traumatic brain injury and how the availability of brain active biolipids affects brain function.
Selected Publications "Accelerant-promoted free radical polymerization of methacrylates by stabilized nitroxide unimolecular initiators: synthesis and characterization." O.E. Ansong; S. Jansen; Y. Wei, Polymer International. (2008), 57(6): 863-871.
"Development and validation of a high-performance liquid chromatography-electrospray mass spectrometry method for the simultaneous determination of 23 eicosanoids." A.J. Blewett; D. Varma; T. Gilles; S. Jansen, Journal of Pharmaceutical and Biomedical Analysis. (2008), 46(4): 653-662.
"Novel N-acyloxytrialkylammonium salts as initiators for free radical polymerization of methacrylates." O.E. Ansong; S. Jansen; Y. Wei, Journal of Materials Chemistry. (2007), 17: 4499-4507.
"A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and eposyeicosatrienoic acids in rat brain tissue." H.F. Yue; S.A. Jansen; K.L. Strauss, Journal of Pharmaceutical and Biomedical Analysis. (2007), 43(3): 1122-1134.
"Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in rat brain tissue and plasma." H.F. Yue; M.R. Borenstein; S.A. Jansen, Journal of Pharmacological and Toxicological Methods. (2005), 52(3): 314-322.
"Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury." J.J. Gopez; H.F. Yue; R. Vasudevan, Neurosurgery. (2005), 56(3): 590-603.
"In vitro tobramycin elution analysis from a novel beta-tricalcium phosphate-silicate-xerogel biodegradable drug-delivery system." M. DiCicco; A. Goldfinger; F. Guirand; S.A. Jansen, Journal of Biomedical Materials Research Part B- Applied Biomaterials. (2004), 70B(1): 1-20.
"Corrosion inhibition by aniline oligomers through charge transfer: a DFT approach." L.T. Sein; Y. Wei; S.A. Jansen, Synthetic Metals. (2004), 143(1): 1-12. |
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