Lower Level

C070. Foundations of Biology (4 s.h.) F. Core: SA .

Foundations of Biology is a one semester Core A course for students not majoring in a natural science. The course consists of three hours of classroom activities and two hours of laboratory each week. The curriculum will focus on major concepts of biology, including: evolution by natural selection; energy, matter and organization of living systems; reproduction and inheritance; growth, development and differentiation; maintenance of dynamic equilibrium; interaction and interdependence of organisms. Instruction will consist primarily of classroom and laboratory activities of various types.

Note: This is a one semester Core Science A course for students not majoring in a natural science. This course is recommended for students majoring in elementary education.

C071. Human Biology (4 s.h.) F S SS. Core: SA.

An introduction to the principles of biology using the human as a model organism. The course covers biomolecules; the heredity, development, structure and function of the human body; and the relationship of humans to their environment. Laboratory requires dissection.

Note: Not available for Biology major credit; no credit if either Biology C083 or C084 is previously taken.

C072. Ecosystems (4 s.h.) S. Core: SB.

Prerequisite: Biology C071.

Ecological principles and energy interactions in ecosystems, elements controlling population size and the resources governing population interactions, with particular emphasis on the influence of human activity on various ecosystems. Laboratory.

Note: Not available for Biology major credit.

C073. Applied Biology (3 s.h.) F. Core: SB.

Prerequisite: Biology C071.

Emphasis on recent development in the application of biological knowledge that benefit humans and the environment. Topics include: Development and production of compounds for treatment of diseases; biological control of insects and weeds; transgenic crops; transgenic animals and their applications. Forensics and medical biotechnology. Human gene therapy, immunology and AIDS.

Note: Not available for Biology major credit.

C074. Plants, Food, World Hunger (3 s.h.) F. Core: SB.

Prerequisite: Biology C071.

Lectures cover the biology of plant growth, physiology, and reproduction; the genetic basis for plant breeding; plant improvement by genetic engineering; the role of crop plants in human nutrition; effects of the Green Revolution; world food production in developed versus developing countries.

Note: Not available for Biology major credit.

C075. Human Heredity (4 s.h.) S SS. Core: SB.

Prerequisite: Biology C071.

Emphasis on the transmission and expression of genetic information in humans. Topics include: introduction to Mendelian and molecular genetics; mutations and the genetic code; hereditary disorders and genetic counseling; the genetics of cancer, and immunity; and implications of genetic technology.

Note: Not available for Biology major credit.

C080. Human Development (4 s.h.) F S. Core: SB.

Prerequisite: Biology C071.

The basic biology of mammalian reproduction and development: sperm and egg production, fertilization, contraception, fetal development, genetic disorders and birth defects, contribution of heredity and environment to human development, and hormone cycles.

Note: Not available for Biology major credit.

C083-C084/H093-H094. General Biology (4 s.h.) F S SS. Core: SA-SB.

General introductory biology for non-biology majors. First semester includes cell physiology (introduction), origins of life, taxonomy, principles of evolution, animal evolution, and a survey of physiology. Second semester includes biological molecules, biochemistry, molecular biology, and genetics. Laboratory required.

C085. Marine Biology (4 s.h.) F SS. Core: SB.

Prerequisite: Biology C071 or Biology C072.

Introduction to life in the oceans, including a survey of marine habitats, associated life forms, their interactions with each other and the transfer of energy within and between ecosystems. Cooperative studies of topics such as: biology of El Nino, over-fishing; introduced marine organisms; biology of coral reefs; destruction of marine wetlands; symbiosis in the oceans; biology of deep sea organisms. One all-day field trip.

Note: Not available for Biology major credit.

Upper Level

0103-0104/H103-H104. Introduction to Biology (4 s.h. each) F S.

Prerequisite: For Biology 0103: successful completion of one year of college chemistry (Chemistry C071, C072 or equivalent) with a grade of C- or better in both semesters and concurrent enrollment in Organic Chemistry (Chemistry 0121 or equivalent). One year of college level calculus is strongly recommended but not required. Biology 0104: successful completion of first semester college chemistry (Chemistry C071 or equivalent) with a grade of C- or better.

Biology 0103 and Biology 0104 may be taken in any order. However, students must complete both courses with a grade of C- or better before they will be allowed to take the second required courses (Biology 0203 and 0204) in the Biology curriculum. Biology 0103 provides an introduction to the fundamental concepts of biochemistry, cell biology, molecular biology and genetics. Topics covered include the structure of important biological macromolecules, enzyme kinetics, metabolic pathways, photosynthesis, cell changes during mitosis and meiosis, DNA replication, transcription, translation and genetic analysis. Biology 0104 covers evolutionary principles, an introduction to ecology, and anatomy and physiology of plants and animals with an emphasis on vertebrate systems. Concepts and facts discussed in lecture will be closely integrated with laboratory observation and experimentation.

Note: This course is the introductory course for Biology majors.

0109-0110. Cooperative Research in Biochemistry (3 s.h.) F S.

Independent research carried out in an off-campus laboratory. A Biochemistry faculty member and the research director of the off-campus laboratory will jointly supervise research. Written permission must be obtained in advance from the supervising faculty member and one of the co-administrators. Student must present a seminar on campus describing the scientific aims of the project, the experimental design, and the conclusions drawn from the experiments.

Note: Restricted to Biochemistry majors enrolled in the Cooperative Program.

0190-0191. Extradepartmental Studies (2-3 s.h.) F S SS.

Approval of the Biology Honors Committee required. Permits students doing independent study projects outside the department to obtain credit for their work. Students must be Biology majors who have completed Biology 0103, 0104, 0203, and W204. Students must obtain a sponsor on the Biology Department faculty to oversee their work and act as a liaison between the outside institution and the Biology Honors Committee. A written research report is required.

Note: Not available for Biology major credit.

0192-0193. Cooperative Studies (2-4 s.h.) F S.

Students obtain a job through the Cooperative Placement Office. Course grade based entirely on a research paper, related in subject matter to the job, and prepared under the supervision of a Biology Department faculty member. The student is responsible for finding a departmental supervisor.

Note: For students enrolled in a Cooperative Program; not for Biology concentration credit.

0195. Independent Study (2-3 s.h.) F S SS.

Research under the direction of a faculty member. Students must obtain a sponsor and approval of the Biology Honors Committee.

Note: Not available for Biology major credit.

0203. Genetics (4 s.h.) S.

Prerequisite: Completion of Biology 0103 and 0104 and Chemistry 0121 and 0122 with a C- or better in each course.

Laboratory and recitation. Examines the basic principles and problems of classical, biochemical, and molecular genetics. Laboratory experiments provide an introduction to genetics and molecular biology.

Note: Required for majors in Biology.

W204. Cell Structure and Function (4 s.h.) F. Core: WI.

Prerequisite: Chemistry 0122.Co-Requisite: Physics 0121 (C- or better in each course).

The chemistry and biological functions of important small molecules and macromolecules of the cell. Concept: the functions of cells are rooted in structures, and the structures themselves derive their characteristics from their chemical components. Laboratory.

Note: Required for majors in Biology.

0227. Principles of Ecology (4 s.h.) S.

Prerequisite: Biology 0103, 0104 and 0203.

Examination of the structure, functions, and interactions of ecosystems at the physical, chemical, and biological levels. Comparative treatment of both terrestrial and marine ecosystems. Field trips and projects are a part of the course.

0233. Mammalian Anatomy (4 s.h.) F.

Prerequisite: One year of General Biology.

A study of the development and gross anatomy of the human. In the laboratory, the dissection of the cat, together with pertinent illustrations from humans and other animals, provides a comparative survey of the anatomical structure of mammals. Laboratory.

0234. Mammalian Physiology (4 s.h.) S.

Prerequisite: Introductory Biology or Biology 0233, one year of chemistry, mathematics, and physics.

Emphasis on the physiology of the normal human; consideration of disease states as counter-illustrations. Certain comparative aspects of physiology are introduced. When appropriate, discussions of function extend to the physical and biochemical level. Laboratory.

0235. General Histology (4 s.h.) S.

Prerequisite: Biology 0104.

A study of the fundamental techniques used in preparing tissues for microscopic examinations, followed by a detailed study of the various types of normal tissues and organs in mammals with emphasis on correlations between structure and function. Laboratory.

0236. Freshwater Ecology (4 s.h.) F.

Prerequisite: Biology 0104.

The interrelationships between biological, chemical, and physical factors in freshwater environments. Lectures and laboratories address general ecological principles (population dynamics, community structure, energy flow, and nutrient cycling) as they apply to plants and animals in lakes, ponds, streams and wetlands.

Note: Up to two field trips.

W237. Marine Environments I (4 s.h.) S SS. Core: WI.

Prerequisite: Junior or senior standing in Biology or Geology and written permission of instructor. Please submit a grade list of completed courses. Knowledge of basic statistics will be helpful.

Introduction to the local marine environments of the northeastern United States through lectures, laboratory, and on-site field work. One required independent research project on the interaction of a common marine organism with its environment. The results will be written up in scientific journal style. Two or three required field trips.

Note: Two or three required field trips.

0238. Marine Environments II (4 s.h.) S SS.

Prerequisite: Biology W237 is co- or prerequisite for Biology 0238, plus junior or senior standing in Biology or Geology and written permission of the instructor. Recommended Prerequisites: Statistics 0022 or 0278. .

Introduction to field research methods and the analysis of data. Lectures emphasize the biological and physical interactions that structure inter-tidal and sub-tidal marine communities. Two team field research projects followed by writing of a research paper in scientific journal style.

Note: Three or four required field trips.

0241. Invertebrate Biology (4 s.h.) S.

Prerequisite: Biology 0104.

An introduction to the biology of the invertebrate phyla including insects. Demonstrations of the patterns of invertebrate evolution by consideration of morphology, behavior, development, physiology, and ecology of representative organisms. Laboratory.

0245. Marine Ecology (4 s.h.) F.

Prerequisite: Biology 0104 or Biology C083 and C084, with final grades of B or better.

A survey of the concepts of aquatic ecology in estuarine and marine ecosystems, emphasizing the organization and maintenance of the major aquatic communities in response to the physical, chemical, and biological characteristics of the environment, modes of energy transfer, physiological adaptation, life history characteristics, and functional morphology. Laboratory exercises stress comparative measurement of biological diversity in the marine environment.

Note: One or more field trips required.

0254. Animal Behavior (4 s.h.) S SS.

Prerequisite: Biology C083 and C084, or Biology 0103 and 0104.

Explores the biological basis of behavior in vertebrate and invertebrate animals. Stresses physiological mechanisms that underlie behavioral responses: the receptor systems that mediate responsiveness to stimuli, and the neural and hormonal systems that integrate and control the behavior. The course also examines social, territorial, and reproductive behavior; the development and evolution of behavior; learning and imprinting; the relationship between circadian rhythms, sun-compass orientation, and animal navigation.

0265. Embryology (4 s.h.) F.

Prerequisite: Biology 0203.

A comparative study of vertebrate embryonic development, including gametogenesis, fertilization, early embryology, and analysis of differentiation of organs, tissues, and cells. The laboratory consists of simple experiments on all aspects of development, supplemented by examination of slides and models. Three hours lecture and three hours laboratory a week.

0292. Junior Honors Seminar (3 s.h.) S.

Prerequisite: Admission by application to the Biology Honors Committee. .

Discussion of research problems and methods as part of laboratory research. Designed to acquaint students with concepts of modern biology and to prepare them for independent research. Students should obtain a faculty sponsor before applying for admission.

Note: Required for majors in Biology.

0300. Directed Readings (3 s.h.) F S SS.

Available as an elective for Biology major credit by petition to the Biology Honors Committee, prior to registration. The student must make a written agreement with a Biology faculty member detailing the course of study to be followed and the mechanisms of evaluation. This agreement must be submitted to the undergraduate adviser and Honors Committee for approval. This course is available only for areas of study in which the department does not present normal course work.

0304. Research Tech. Neuroscience (4 s.h.) F.

This course is intended to give students a hands-on approach to experimental neurobiology. Sensory input, central processing and motor output will be explored using preparations that include: vital staining and synaptic plasticity of invertebrate neuromuscular units; action potentials from plants; monitoring and modifying electric discharge patterns of weakly electric fish; responses of crayfish stretch receptors; mapping and physiological properties of visual units in the frog brain; bursting cells in mollusk ganglia. Students will learn extra-cellular and intra-cellular single unit physiological recording and stimulating. Modern laboratory computers will process physiological signals. Independent projects based on earlier preparations will be carried out towards the end of the semester.

0310. Evolution (3 s.h.) F.

Prerequisite: Completion of Biology 0203 (or equivalent majors level genetics course) with a grade of C- or better.

A lecture and discussion course for upper-level science majors and graduate students. Topics covered include Darwinism and neo-Darwinian theory, including adaptation, natural selection, sexual selection, and speciation.

0315. Behavioral and Neural Genetics (3 s.h.) F.

Prerequisite: Completion of Biology 0203 (or equivalent majors-level genetics course) with a grade of C- or better.

A lecture and discussion class for upper-level science majors and graduate students. We discuss experiments in which genetic and molecular techniques are used to analyze the mechanisms underlying behavior. We will analyze the effects of mutations on simple reflex responses to chemical stimuli and light, complex sexual behaviors, and endogenous phenomena such as circadian rhythms, and learning that modify behaviors.

0316. Tropical Marine Biology: Belize (4 s.h. An Inter-session Course)

Prerequisite: Junior or Senior standing and at least one year of introductory lab biology. Special exceptions only with instructor's permission .

An introduction to the largest coral barrier reef in the Atlantic Ocean. Course lectures begin at Temple (Approximately Dec 29-Jan 31; holidays excluded) followed by a week of lectures, field trips and field or laboratory projects in Belize. Lectures include coral biology, reef geology and ecology, coral reef microbiota, food chains and nutrient transfer in coral reefs, reef community organization, the biology of reef fishes, commensal and symbiotic interactions of reef organisms, and other appropriate topics. Group student team projects and lectures are required.

0317. General Microbiology (4 s.h.) S.
Co-Requisite: Biology 0203 and Chemistry 0122.

A general survey of bacteria and archaea. Topics include: classification; physiology, growth, and environmental impact; genetics and gene recombination; evolutionary relationships. Laboratory topics include pure culture, identification, growth characteristics, and genetics.

0320. Human Genetics (3 s.h.) F.

Prerequisite: Biology 0203 or permission of instructor.

A lecture course in human heredity, emphasizing the mechanisms of inheritance and gene action in humans. Topics covered are molecular genetics, population genetics, and patterns of gene transmission.

0322. Plant Genetics (3 s.h.) S.

Prerequisite: Biology 0203.

Current molecular and genetic analyses of classical problems in the genetics of higher plants.

0324. Molecular Biology (3 s.h.) F.

Prerequisite: Biology 0203 or 0102, with a grade of C- or better and Chemistry 0122.

A comprehensive introduction to molecular genetics and the biochemistry of DNA, RNA, and proteins. The structure and expression of genes in both prokaryotes and eukaryotes will be discussed with special emphasis on DNA replication, transcription, and translation. Current journal articles covering recent developments in modern molecular biology and genetic engineering will be covered.

0325. Research Techniques in Molecular Biology (4 s.h.) S.

Prerequisite: A grade of B or better in Biology 0203 and permission of the instructor. Biology 0324 is recommended but not required.

Laboratory instruction in the techniques used in modern molecular biology and molecular genetics. This course takes a problem-oriented approach toward teaching the methods of DNA and RNA analysis that are used in determining the structure and function of genes. Practical experience in the preparation of DNA , modern cloning methods, restriction enzyme mapping , hybridization analysis, DNA sequencing, and PCR techniques will be provided. Students will carry out a research project during the course.

0328. Virology (3 s.h.) F.

Prerequisite: Biology 0203 -0204 or permission of the instructor.

The role of viruses in human diseases, and their potential as tools for research and clinical interventions. Viral induced diseases in man (smallpox, polio, rabies, hepatitis, herpes, and influenza); recently discovered viruses such as HIV and HTLV-1. Virus-host interactions and the mechanisms involved in disease processes, therapeutic strategies, and vaccines. Strategies for viral entry, evasion of the immune system, transmission, and the subversion of protein. Potential uses of viruses as vector for gene therapy of genetic disorders, cancers, and infectious diseases.

0329. Development Genetics (3 s.h.) F.

Prerequisite: Biology 0203 and 0204.

The role of genes during the periods of determination and differentiation in eukaryote development. Emphasis on the regulation of gene function and the relationship between gene function and the molecular and developmental interactions which culminate in the adult phenotype.

0330. Cell Biology (3 s.h.) F.

Prerequisite: Biology 0204 .

Recent developments in cell biology will be discussed. Topics will include the cytoskeleton, cell cycle, and cell motility.

0333. Advanced Techniques in Microscopy (3 s.h.) F.

This course will provide a survey of modern techniques in microscopy. Students will acquire a thorough grounding in general principles of optics and conventional microscopy, and learn the theory of many methods current in Biology and medicine, fluorescence, confocal microscopy, video microscopy, and digital image processing and analysis.

0340. Advanced Invertebrate Biology (3 s.h.) F.

Prerequisite: Biology 0241 and 0242 or permission of instructor.

A study of the mechanisms of development using invertebrates as model systems. The class will address developmentally significant questions relevant to both vertebrates and invertebrates, including: role of lineage versus position in determination, induction of polarity, genetics and molecular biology of segmentation, and path-finding in the nervous system. Emphasis is on the advantages of comparative biology and invertebrate systems for analyzing patterns in development.

0344. Research Techniques (4 s.h.) S.

Prerequisite: Chemistry 0371 or Biology 0375 or permission of instructor.

Laboratory instruction in techniques used to investigate biological problems. Techniques include spectrophotometry, column chromatography, various types of electrophoresis, separation of macromolecules, two-dimensional protein separation, affinity chromatography, isolation of plasmid DNA, Western Blot, immunoassay, enzyme kinetics, and radioisotope techniques. If time permits, students will be given a small research project.

0352. Neurobiology (3 s.h.) S.

Prerequisite: Permission of instructor.

A comparative survey of vertebrate and invertebrate neurobiology intended to acquaint the student with structure and function at the level of the cell or small groups of cells.

0354. Neural Basis of Animal Behavior (3 s.h.) F.

Prerequisite: One semester of neurobiology.

An exploration of the relationship of neural activity and connectivity to behavior. Topics include motor control, object recognition, and learning. Examples from both vertebrate and invertebrate species. Analytic and synthetic approaches.

0355. Biological Clocks (3 s.h.) S.

Prerequisite: One year of General Biology.

This is a lecture course dealing with the subject of the rhythms of life, daily and seasonal. The nature of the clock, the means for resetting the clock, the clock's use in navigation, and the relationship of the clock to the environment.

0356. Organization and Development of the Nervous System (3 s.h.) F.

Prerequisite: Biology 0204 or permission of instructor.

This course covers developmental, anatomical, and integrative aspects of the nervous system. The relationship of form to function will be studied in a variety of systems both invertebrate and vertebrate. The course is intended to complement Neurobiology 0352/0452 so that students will have a perspective on neuroscience ranging from the molecular to the systems level.

0363. Genetic Control of Mammalian Development (3 s.h.) F S.

This course covers mammalian embryogenesis; macromolecular synthesis and onset of zygotic gene activity; the effects of the male and female genomes on development; the effect of chromosome and gene imprinting on development; the production of, analysis of and use of, transgenic and knock out mice; the expression of protoncogenes and oncogenes during development; and, the expression of homeoboxes and interacting factors during development. With the exception of normal development, all of the topics are taught from journal articles.

0364. Biochemical Embryology (3 s.h.) F.

Prerequisite: Biology 0203 and 0204.

Examination of current models concerning cyto-differentiation in vertebrate embryos, and some of the data that has been used in support of these models.

0365. Mammalian Development (3 s.h.) S.

Prerequisite: Biology 0203 and 0265 or permission of instructor.

Mammalian development will be taught using primary references. Course will cover gametogenesis, fertilization and pre- and post-implantation stages. Genetic mutations and experimental procedures will be used to define developmental interactions.

0367. Endocrinology (3 s.h.) F.

Prerequisite: General Biology and Organic Chemistry.

Broad coverage of "chemical messengers," occurrence, biochemistry, and physiology. Vertebrate endocrinology with minor treatment of invertebrates and plants.

0370. Comparative Animal Physiology (3 s.h.) S.

Prerequisite: Biology 0103, 0104 and 0233 or equivalent; Chemistry C071 and C072 or equivalent.

An in depth study of fundamental principles in comparative physiology, with emphasis on the development of the nervous system in vertebrates. We will study the neural basis of behavior and perception, using ideas of signal propagation, sensory information, neural processing, and chemical signaling. We will also study temperature regulation, osmoregulation, and respiration..

0371. Cell Proliferation (3 s.h.) S.

Prerequisite: Biology 0203 and W204 or permission of instructor.

Cell proliferation and its control: model systems, comparisons of proliferating cells with non-proliferating cells, controls of cell division and how that control is modified in proliferative diseases such as cancer, and the relationships between proliferation and differentiation. Readings will be taken from the literature.

0374. Physical Biochemistry (3 s.h.) S.

Prerequisite: Chemistry C071 and C072, C073 and C074, or C091 and C092, two semesters of calculus, and one semester of calculus-based physics.

The course covers those aspects of physical chemistry and computer simulation of use to biochemists in understanding the physical properties of biologically significant molecules and structures.

0375. General Biohemistry I (3 s.h.) F.

Prerequisite: Chemistry 0122 and Biology 0103 or permission of instructor.

Properties of water (pH and buffers); Chemistry of amino acids and proteins including non-covalent interactions; carbohydrates, nucleotides and nucleic acids; lipids and membranes; enzyme mechanisms and kinetics; control of enzyme activity; biogyenergetics and oxidative metabolism; and chemistry of photosynthesis.

0376. General Biochemistry II (3 s.h.) S.

Prerequisite: Chemistry 0371.

Emphasis on the biochemical reactions in various metabolic pathways. Regulation and integration of metabolism. Signal Transduction. Oxidative phosphorylation. Transcription - Translation.

0381. Membrane Biochemistry and Biophysics (3 s.h.) S.

Prerequisite: Biology 0204, 0234, or permission of instructor.

Elementary treatment useful for pre-professional students. Membrane equilibrium, diffusion, proton motive, cellular homeostasis, ionic basis of nerve and muscle function, purification, cloning, and molecular physiology of channels, porters, and pumps.

0384. Organogenesis (3 s.h.) S.

Prerequisite: Biology 0265 or permission of instructor.

An analysis, based upon the experimental literature, of the processes which result in organ formation during embryonic development. The emphasis is on the correlation between extra-cellular signals and cellular responses. Topics include organization of the cytoskeleton, extra-cellular matrix and cell membrane and responses to the extra-cellular environment, which result in the formation of specific organs, such as central nervous system, sense organs, digestive organs, and kidney. .

0385. Contemporary Biology (3 s.h.) F.

Prerequisite: Biology 0204, 0234, or permission of instructor.

Advanced discussion of selected topics.

0387-0388. Advanced Special Topics in Biochemistry (3 s.h.) F S.

Prerequisite: Chemistry 0371 or permission of instructor.

Advanced lecture course. Subject matter varies from semester to semester.

0391 and 0392. Honors Research (4, 2-4 s.h. respectively) F S.

Prerequisite: Senior standing and a GPA of 3.0 or better. Available for Biology major credit (one elective course) with the completion of both courses; by recommendation of the faculty sponsor and approval of the Biology Honors Committee. .

Research under the supervision of a faculty member. A written report and an oral presentation of the student's research are required in Biology 0392. Upon successful completion, the student is awarded Distinction in Biology.

0393 and 0394. Research in Biochemistry (3 s.h.) F S.

Prerequisite: Available for Biochemistry major. Written approval must be obtained in advance from the faculty member and one of the co- aministrators.

Research in the laboratory of one of the Biochemistry faculty. A presentation of the student's research is required in Biology 0394. Upon completion of Biology 0393 and Biology 0394, students may also petition for them to be counted as a Biochemistry elective.

0396. Honors Seminar in Biochemistry (3 s.h.) S.

This course required for graduation with honors. Student presentation of research done in this course (and Biology 0393 and 0394) or a comprehensive presentation of a topic selected jointly by student and adviser. Emphasis placed on analysis of experimental techniques, quantitative interpretation of the data, logical analysis of controls, and implication of the results.

Note: Admission to this course and the honors track, as well as recommendation for graduation with honors must be approved by the Biochemistry Committee. This course required for graduat